Eph receptors and ephrins demarcate cerebellar lobules before and during their formation
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منابع مشابه
Eph receptors and ephrins demarcate cerebellar lobules before and during their formation
The formation of the ten cerebellar lobules is an unsolved problem in brain development. We report a screen for the four subfamilies of Eph receptors and their ligands (ephrins) in developing mouse cerebellum, using soluble receptor-immunoglobulin and ligand-immunoglobulin fusion proteins, and antibodies against EphA and ephrin-B proteins. Our results identify Eph receptors and ephrins as the f...
متن کاملEph receptors and ephrins.
Eph receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility. Eph signaling is crucial for the development of many tissues and organs including the nervous and cardiovascular systems. Both Ephs and ephrins are membrane-bound and their interactions at sites of ...
متن کاملEphrins and Eph Receptors
chemorepulsive factors. Integrin heterodimers are primary ECM receptors, which can exist in different functional states with respect to their affinity or avidity for ECM proteins (11, 35), and directed cell motility on ECM is promoted by targeted localization of high-affinity integrins at the leading edge of migrating cells (40). There is now mounting evidence that both chemoattractant and chem...
متن کاملEphrins and Eph Receptors
chemorepulsive factors. Integrin heterodimers are primary ECM receptors, which can exist in different functional states with respect to their affinity or avidity for ECM proteins (11, 35), and directed cell motility on ECM is promoted by targeted localization of high-affinity integrins at the leading edge of migrating cells (40). There is now mounting evidence that both chemoattractant and chem...
متن کاملEphrins and their Eph receptors: multitalented directors of embryonic development.
Ephrins are membrane-bound ligands for the Eph family of protein tyrosine kinase receptors. Recent genetic studies have indicated that these molecules play key roles in diverse biological processes such as the development of the nervous system and angiogenesis. In the nervous system, they provide positional information by employing mechanisms that involve repulsion of migrating cells and growin...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 1999
ISSN: 0925-4773
DOI: 10.1016/s0925-4773(99)00154-9